产品信息
抗原名称
αvβ3 integrin
商品描述
Cyclo (-RGDfK) is a potent and selective <b>αvβ3 integrin</b> inhibitor.
分子量
717.69
纯度
≥98%
可溶性
Water ：100 mg/mL (139.34 mM)
In vitro(体外研究)
The constant of affinity (KD) of Cyclo (-RGDfK-) for purified integrin is 41.70 nM. Cyclo (-RGDfK) is reacting with HEK293(β3) cells moderately. Cyclo(-RGDfK-) modified micelles shows strong affinity to T-24 cells and strong inhibitory effect on the proliferation of T-24 cells.
In vivo(体内研究)
In athymic mice bearing α(v)β(3)-integrin-positive C6 gliomas, Cyclo (-RGDfK-) modification induces less tumor progression, less tumor metabolic activity, fewer intratumoral vessels.
背景
分子式
C29H42F3N9O9
CAS号
161552-03-0(freebase)
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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