Microsomal prostaglandin E₂ synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) are key enzymes in the synthesis of PGE₂ (Item No. 14010) and leukotrienes (LTs), respectively. PGE₂ and LTs are bioactive lipids that contribute to a broad range of pathologies, including inflammation and various forms of cancer.^1,2 Pirinixic acid aminothiazole is a dual inhibitor of mPGES-1 and 5-LO (IC₅₀s = 0.4 and 0.2 µM, respectively).³ It is a weak inhibitor of COX-1 and -2 and has no effect on 12- and 15-LO isoforms.³ Pirinixic acid aminothiazole reduces the synthesis of PGE₂ and LTC₄ (Item No. 20210) during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response.³

≥98%