产品信息
抗原名称
ATM
商品描述
AZD0156是一种高效选择的ATM抑制剂，能够抑制ATM介导的信号通路，阻碍DNA损伤修复等。
分子量
461.56
纯度
＞98%
可溶性
Ethanol ：2 mg/mL (4.33 mM)
In vitro(体外研究)
AZD0156 shows sub-nanomolar potency in cell based assays of ATM inhibition with selectivities of greater than 1000 fold over other members of the PIKK family of enzymes.
In vivo(体内研究)
AZD0156 is a permeable, highly soluble compound with excellent preclinical pharmacokinetic properties including oral bioavailability. AZD0156 shows robust efficacy in mouse xenograft models after oral administration when combined with DSB inducing agents. AZD0156 is currently undergoing early clinical assessment.
背景
别名
AZD-0156; AZD 0156
分子式
C25H31N5O3
CAS号
1821428-35-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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