产品信息
抗原名称
APE1(Ref-1)
商品描述
E3330 is a potent and selective <b>APE1(Ref-1)</b> inhibitor, which suppressed NF-kappa B DNA-binding activity.
分子量
378.46
纯度
≥98%
可溶性
DMSO : 70 mg/mL (185 mM)
Ethanol : 70 mg/mL (185 mM)
Ethanol : 70 mg/mL (185 mM)
外观
red to orange powder
In vitro(体外研究)
E3330 affects hemangioblast development in vitro via inhibition of Ape1 redox activity. E3330 inhibits the growth of human pancreatic cancer cell line PANC1, XPA1, MIAPACA, BxPC3, and PK9. E3330 also promotes exit of cell cycle in PANC1 cells, inhibits the DNA-Binding activity of HIF-1α and migration of pancreatic cancer cells. In JHH6 cells, E3330 prevents the functional activation of NF-κB via the alteration of APE1 subcellular trafficking and reduces IL-6 and IL-8 expression induced by TNF-α and FAs accumulation through blockage of the redox-mediated activation of NF-κB.
In vivo(体内研究)
In mice with endotoxin-mediated hepatitis, E3330 (300 mg/kg, p.o.) attenuates the elevation of plasma tumor necrosis factor activity and protectes mice from liver injury. In Rat model, E3330 (100 mg/kg, p.o.) also protectes rats from severe liver injury induced with endotoxin plus galactosamine.
背景
分子式
C21H30O6
CAS号
136164-66-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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