产品信息
抗原名称
Notch
商品描述
FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.
分子量
438.52
纯度
>98%
可溶性
DMSO : 43.9 mg/mL (100 mM)
Ethanol : 8.8 mg/mL (20 mM)
Ethanol : 8.8 mg/mL (20 mM)
外观
黄色粉末
In vitro(体外研究)
In HeLa NotchΔE-eGFP cells, FLI-06 blocks Notch trafficking and processing. FLI-06 changes the maturation pattern of APP and abolishes the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid β. FLI-06 disrupt the Golgi apparatus, and inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which is accompanied by a tubule-to-sheet morphological transition of the ER.
In vivo(体内研究)
FLI-06 (50 μM) inhibits endogenous Notch signaling in zebrafish embryos.
背景
别名
FLI06；FLI 06
分子式
C25H30N2O5
CAS号
313967-18-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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