产品信息
商品描述
ML204 hydrochloride is a novel, potent, selective TRPC4 channel inhibitor with IC50 of 0.96 uM.
分子量
262.78
纯度
＞98%
可溶性
H2O : ≥ 30 mg/mL (114.16 mM)
In vitro(体外研究)
ML204 inhibited TRPC4β-mediated intracellular Ca2+ rise. ML204 at 10 μm showed >50% inhibition in only 7 of 68 binding assays for 68 GPCRs, ion channels, and transporters. ML204 afforded good selectivity (19-fold) against TRPC6 channels and more modest selectivity against TRPC3 and TRPC5 (9-fold) channels.
In vivo(体内研究)
The selectivity of ML204 show no appreciable block by 10-20 μm ML204 of TRPV1, TRPV3, TRPA1, and TRPM8, as well as KCNQ2 and native voltage-gated sodium, potassium, and calcium channels in mouse dorsal root ganglion neurons.
背景
别名
ML204 HCl
分子式
C15H19ClN2
CAS号
2070015-10-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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