产品信息
抗原名称
PDGFR,PDGFR
商品描述
Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation.
分子量
862.74
可溶性
DMSO ：100 mg/mL (115.9 mM)
Ethanol ：1 mg/mL (1.15 mM)
Ethanol ：1 mg/mL (1.15 mM)
外观
黄色结晶粉末
In vitro(体外研究)
Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits platelet-derived growth factor (PDGF)-stimulated MG63 cell proliferation by binding to PDGF-BB and its receptor and down-regulating the PDGFR-beta signaling pathway. Pre-incubation of PDGF-BB with sennoside B inhibits the phosphorylation of pathway components including Ak strain transforming protein (AKT), signal transducer and activator of transcription 5 (STAT-5) and extracellular signal-regulated kinase 1/2 (ERK1/2). It also inhibits bovine serum monoamine oxidase with IC50 of 9 μM.
In vivo(体内研究)
LD50: Mice 5000 mg/kg (i.g.); Rats 5000mg/kg (i.g.).
背景
别名
番泻苷 B
分子式
C42H38O20
CAS号
128-57-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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