3S-5-甲基-3-4-吗啉基甲基-2-3-二氢-1-4-恶嗪并-2-3-4-Hi-吲哚-6-基-1-萘基-甲酮甲烷磺酸酯-1-1_131543-25-4_Absin
产品信息
商品描述
(−)-WIN 55,212-3 is an aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB2 receptor, blocking both the stimulating action of CP 55,940 (pA2 = 6.1) and the inverse agonism of SR 144528 (Item No. 9000491) (pEC50 = 5.3).1 (−)-WIN 55,212-3 neither antagonizes nor mimics the effects of Δ9-THC on rat cerebellar membranes, which presumably express the CB1 receptor.2,3 (−)-WIN 55,212-3 also weakly antagonizes the melatonin MT1 and muscarinic M4 receptors but has no effect on several other G protein-coupled receptors.1
分子量
522.6
纯度
≥98%
背景
分子式
C27H26N2O3 • CH3SO3H
CAS号
131543-25-4
制备和贮存
保存方式
Store at -20℃
参考图片
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