Free fatty acid receptor 3 (FFAR3; GPR41) is a G protein-coupled receptor activated by short chain fatty acids (SCFAs). It is expressed in adipose tissue, the gastrointestinal tract, and the peripheral nervous system, and it is involved in SCFA-dependent energy regulation.¹ AR420626 is a selective agonist of FFAR3 (GPR41; IC₅₀ = 117 nM) that does not activate the related receptor FFAR2 (GPR43) at concentrations up to 100 µM.² At 10 µM, it can stimulate a 1.26-fold increased release of glucagon-like peptide-1 from colonic crypt cultures.³

≥95%