产品信息
抗原名称
PI3Kα ,PI3Kβ ,PI3Kδ ,PI3Kγ ,mTOR
商品描述
GSK1059615是一种PI3Kα/β/δ/γ (可逆的)和mTOR的双重抑制剂，IC50分别为0.4 nM/0.6 nM/2 nM/5 nM和12 nM。GSK1059615也抑制mTOR，IC50为12 nM。GSK1059615抑制PI3K通路，诱导细胞停滞在G1期，可观察到凋亡。GSK1059615有效作用于胸腺癌细胞。
分子量
333.36
纯度
>98%
可溶性
DMSO ：2mg/ml(6 mM)
外观
Powder
In vitro(体外研究)
The pyridinylquinoline derivative GSK1059615 is a novel, ATP-competitive, and reversible inhibitor of the class I family of PI3Ks. GSK1059615 inhibits PI3K signaling, induces G1 arrest and apoptosis, especially in breast tumor cells. Data summarized in another review also shows that GSK1059615 inhibits PI3Kα, β, γ and δ, with Ki of 0.42 nM, 0.6 nM, 0.47 nM and 1.7 nM, respectively. Another report shows that GSK1059615 inhibits PI3Kα with IC50 of 2 nM. In T47D and BT474 cancer cells, GSK1059615 inhibits the phosphorylation of Akt at S473, with IC50 of 40 nM.
In vivo(体内研究)
In xenograft mice models of BT474 or HCC1954 breast cancer cells, GSK1059615 (25 mg/kg) effectively inhibits tumor growth.
背景
别名
GSK 1059615; GSK-1059615
分子式
C18H11N3O2S
CAS号
958852-01-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
本文来自投稿，不代表本人立场，如若转载，请注明出处：http://www.iamyjet.com/article/13332.html