SR 2595 is an inverse agonist of PPARγ (IC₅₀ = 30 nM) that represses both transactivation in a promoter:reporter assay and expression of the adipogenic marker fatty acid-binding protein 4 in differentiating murine preadipocytes.¹ Repression of PPARγ with SR 2595 promotes osteogenesis, as measured by calcium phosphatase deposition, in cultured human mesenchymal stem cells (MSCs).¹ SR 2595 also increases expression of bone morphogenetic proteins BMP2 and BMP6 in MSCs.¹

≥98%