产品信息
抗原名称
mutant EGFR,BTK
商品描述
Olmutinib is a novel third-generation epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor (TKI). Also a potent inhibitor of Bruton‘s tyrosine kinase.
分子量
486.59
纯度
>98%
可溶性
DMSO : 90 mg/mL (185 mM)
Ethanol : 22 mg/mL (45.2 mM)
Ethanol : 22 mg/mL (45.2 mM)
外观
Powder
In vitro(体外研究)
HM61713 causes potent inhibition in cell lines H1975 (L858R and T790M) and HCC827 (exon 19 deletion). It has a low potency for NSCLC cell line H358 harboring wild-type EGFR (GI50 of 2225 nM).
In vivo(体内研究)
HM61713 has a half-life of over 24 h for EGFR inhibition. In the in vivo studies of xenograft models with grafts of H1975 and HCC827, HM61713 is active against the tumors without showing any side effects.
背景
别名
奥莫替尼；HM 71224；HM71224
分子式
C26H26N6O2S
CAS号
1353550-13-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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