产品信息
抗原名称
TLR8
商品描述
Motolimod (VTX-2337) is a novel TLR8 agonist that activates NK cells and augments ADCC.
分子量
458.6
纯度
>98%
可溶性
Ethanol ：12 mg/mL (26.2 mM)
DMSO ：51 mg/mL (111.2 mM)
DMSO ：51 mg/mL (111.2 mM)
外观
Powder
In vitro(体外研究)
VTX-2337 stimulates the production of both TNFα with EC50 of 140 nM and IL-12 with EC50 of 120 nM in PBMCs. In monocytes and mDCs, VTX-2337 selectively induces the production of TNFα and IL-12 via NF-κB activation. VTX-2337 also stimulates IFNγ production from NK cells, augments the lytic function of NK cells and enhances ADCC.
In vivo(体内研究)
In an ovarian cancer mouse model, TX-2337 enhances the effect of pegylated liposomal doxorubicin (PLD).
背景
别名
VTX 2337,VTX2337,VTX-378
分子式
C28H34N4O2
CAS号
926927-61-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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