产品信息
抗原名称
PKM2
商品描述
DASA-58 is a highly specific small molecule PKM2 activator. DASA-58 inhibits LPS-induced Hif-1a and IL-1b, as well as the expression of a range of other Hif-1a-dependent genes.
分子量
453.53
纯度
>98%
可溶性
DMSO: ≥ 35 mg/mL
外观
Powder
In vitro(体外研究)
DASA-58 inhibits LPS-induced Hif-1α and IL-1β, as well as the expression of a range of other Hif-1α-dependent genes in primary BMDMs, and also inhibits glycolysis and the accumulation of succinate in LPS-activated macrophages. In PC3 cells, DASA-58 impairs stromal-induced EMT program by restoring PK activity and abrogating the nuclear translocation of PKM2, as well as its association with HIF-1α. DASA-58 also dramatically reduces (~6-fold) CAFs-induced lung metastases formation in PC3 cells.
In vivo(体内研究)
DASA-58 (40 μM) affects EMT of prostate cancers and tumor dissemination in SCID mice.
背景
别名
DASA58; DASA 58
分子式
C19H23N3O6S2
CAS号
1203494-49-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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