产品信息
抗原名称
HDAC3 ,HDAC1,HDAC2
商品描述
BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50?= 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively).
分子量
214.2
纯度
>98%
可溶性
DMSO: ≥ 48 mg/mL
外观
Powder
In vitro(体外研究)
BG45 causes significant cell growth inhibition and induces caspase-dependent apoptosis in a series of MM cells. In RPMI8226 cells, BG45 synergistically enhances bortezomib-induced cytotoxicity.
In vivo(体内研究)
In mice bearing MM.1S xenograft of human MM, BG45 (50 mg/kg, i.p.) significantly inhibits MM tumor growth. When in combination with bortezomib, BG45 (50 mg/kg, i.p.) enhances bortezomib-induced cytotoxicity.
背景
别名
BG-45,BG 45
分子式
C11H10N4O
CAS号
926259-99-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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