产品信息
抗原名称
Menin-MLL interaction
商品描述
MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.
分子量
375.55
纯度
>98%
可溶性
DMSO ：19 mg/mL warmed (50.59 mM)
Ethanol ：19 mg/mL warmed (50.59 mM)
Ethanol ：19 mg/mL warmed (50.59 mM)
外观
Powder
In vitro(体外研究)
In HEK293 cells, MI-3 accesses the protein target and effectively inhibits the menin-MLL-AF9 interaction. MI-3 effectively blocks MLL fusion protein-mediated leukemic transformation by downregulating the expression of target genes required for MLL fusion protein oncogenic activity. In human MLL leukemia cell lines harboring different MLL translocations, MI-3 effectively blocks cell proliferation, and induces apoptosis.
背景
别名
MI3,MI 3,Menin-MLL inhibitor 3; Thieno[2,3-d]pyrimidine, 4-[4-(4,5-dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)
分子式
C18H25N5S2
CAS号
1271738-59-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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