产品信息
抗原名称
CBFβ-SMMHC
商品描述
AI-10-49 selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1.
分子量
660.52
纯度
>98%
可溶性
DMSO 100 mg/mL (151.39 mM)
Ethanol 100 mg/mL warmed (151.39 mM)
Ethanol 100 mg/mL warmed (151.39 mM)
外观
Powder
In vitro(体外研究)
AI-10-49 displays specific growth inhibition of inv(16)-positive cell line ME-1. AI-10-49 selectively binds to CBFβ-SMMHC, disrupts its binding to RUNX1, and restores RUNX1 transcriptional activity.
In vivo(体内研究)
In mice transplanted with Cbfb+/MYH11;Nras+/G12D leukemic cells, AI-10-49 (200 mg/kg, i.p.) reduces leukemia expansion.
背景
别名
AI 1049,AI1049
分子式
C30H22F6N6O5
CAS号
1256094-72-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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