产品信息
抗原名称
MALT1
商品描述
MI-2 (MALT1 inhibitor) 是不可逆的MALT1抑制剂，其IC50为 5.84 μM。
分子量
455.72
纯度
＞98%
可溶性
DMSO 91 mg/mL (199.68 mM)
Ethanol 21 mg/mL (46.08 mM)
Ethanol 21 mg/mL (46.08 mM)
外观
Powder
In vitro(体外研究)
MI-2 inhibits MALT1 functions in ABC-DLBCL cell lines with excellent cell penetration. MI-2 produces selective growth inhibition for MALT1-dependent cell lines with GI50 of 0.2, 0.5, 0.4, and 0.4 礛 in HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells, whereas the ABC-DLBCL MALT1-independent cell lines, U2932 and HLY-1, and the two GCB-DLBCL cell lines were resistant.
In vivo(体内研究)
MI-2 (350 mg/kg) is nontoxic to mice. MI-2 (25 mg/kg/day i.p.) profoundly suppresses the growth of both the TMD8 and HBL-1 ABC-DLBCL xenografts, whereas it has no effect on the growth of OCI-Ly1 tumors.
背景
别名
MI2,MI-2
分子式
C19H17Cl3N4O3
CAS号
1047953-91-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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