产品信息
抗原名称
CaMKII
商品描述
KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).
分子量
599.03
纯度
>98%
可溶性
DMSO ：100 mg/mL (166.93 mM)
Water ：92 mg/mL (153.58 mM)
Water ：92 mg/mL (153.58 mM)
外观
Powder
In vitro(体外研究)
KN-93 inhibits dopamine formation in PC12h cells by modulating the reaction rate of TH to reduce the Ca(2+)-mediated phosphorylation levels of the TH molecule. KN-93 inhibits serum-induced fibroblast cell growth with IC50 of 8 μM, and induces apoptosis after prolonged G1 arrest. KN-93 inhibits androgen receptor activity and p53-independently induces cell death in PCa cells.
In vivo(体内研究)
KN-93 (5 μg) ameliorates levodopa-induced dyskinesia by lowering the expression of pGluR1S845 in a rat model of Parkinson’s disease. In MRL/lpr Foxp3-GFP mice, KN-93 results in a significant induction of Treg cells in the spleen, peripheral lymph nodes and peripheral blood, and decreases skin and kidney damage.
背景
别名
KN 93; KN93
分子式
C26H29ClN2O4S.H3O4P
CAS号
1188890-41-6；1913269-12-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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