产品信息
抗原名称
DNA methyltransferase
商品描述
RG108 is an inhibitor of DNA methyltransferase with IC50 of 115 nM, does not cause trapping of covalent enzymes.
分子量
334.33
纯度
>98%
可溶性
Ethanol ：33.4 mg/mL (100 mM)
DMSO ：33.4 mg/mL (100 mM)
DMSO ：33.4 mg/mL (100 mM)
外观
Powder
In vitro(体外研究)
RG108 effectively blocks DNA methyltransferases in vitro and does not cause covalent enzyme trapping in human cell lines. Incubation of cells with low micromolar concentrations of RG108 results in significant demethylation of genomic DNA without any detectable toxicity. Intriguingly, RG108 causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences. In another study, the synthesis and in vitro analysis of a biotinylated RG108 conjugate is investigated to evaluate the interactions with DNA methyltransferase enzymes. In a recent study, it is shown RG108 can significantly reduce the DNA methyltransferases activity in SM derived iPS cells as compared to the native SMs.
背景
别名
RG-108，RG 108，N-Phthalyl-L-tryptophan
分子式
C19H14N2O4
CAS号
48208-26-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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