产品信息
抗原名称
ALK2,ALK1,ALK6,ALK3
商品描述
K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.
分子量
352.38
纯度
>98%
可溶性
DMSO : ≥ 58.6 mg/mL (166.30 mM)
外观
white to beige Powder
In vitro(体外研究)
K02288 dose-dependently inhibits BMP4- and BMP6- induced Smad1/5/8 phosphorylation in C2C12 cells without affecting TGF-β-BMP signaling.
In vivo(体内研究)
In Zebrafish Embryos, K02288 induces a dorsalized phenotype in a dose dependent manner without effect om intersomitic vessel (ISV) formation.
背景
别名
K02288；K 02288；K-02288
分子式
C20H20N2O4
CAS号
1431985-92-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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