产品信息
抗原名称
p53 ,SIRT2 ，SIRT1 ，SIRT3
商品描述
Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 (IC50=21 uM) and SIRT2 (IC50= 10 uM) inhibitor as well as p53 activator.
分子量
454.63
纯度
98%
可溶性
DMSO ：98 mg/mL (215.55 mM)
Water ：98 mg/mL warmed (215.55 mM)
Water ：98 mg/mL warmed (215.55 mM)
外观
Powder
In vitro(体外研究)
Tenovin-6 is a more water-soluble analog of tenovin-1. Tenovin-6 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 of 21 μM, 10 μM, and 67 μM, respectively.
In vivo(体内研究)
Tenovin-6 (50 mg/kg, i.p.) inhibits the growth of tumor in mice.
背景
别名
Tenovin 6; Tenovin6
分子式
C25H34N4O2S
CAS号
1011557-82-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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