产品信息
抗原名称
mitochondrial pyruvate carrier
商品描述
UK-5099 is an inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).
分子量
288.31
纯度
>98%
可溶性
DMSO : ≥ 50 mg/mL (173.43 mM)
外观
yellow to tan powder
In vitro(体外研究)
UK-5099 covalently binds to Mpc and blocks pyruvate transport. UK-5099 enhances aerobic glycolysis and decreases mitochondrial oxidative phosphorylation in LnCap cell in vitro, which is accompanied by increasing proportion of side population (SP) fraction, higher level of stemness markers expression and exhibiting high resistance to chemotherapy. UK5099 enhances stem-like phenotype of prostatic cancer cell through metabolic shift from oxidative phosphorylation to aerobic glycolysis. UK-5099 suppresses proliferation and arrested LnCap cell cycle at G1/G0.
In vivo(体内研究)
UK-5099 slows the growth of patient-derived xenograft (PDX) tumors in mice without severe loss of animal body weight.
背景
分子式
C18H12N2O2
CAS号
56396-35-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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