产品信息
抗原名称
PRMT5
商品描述
HLCL-61 is a first-in-class small-molecule inhibitor of PRMT5 for treatment of acute myeloid leukemia.
分子量
380.91
纯度
>98%
可溶性
DMSO: ≥ 30 mg/mL
外观
Powder
In vitro(体外研究)
HLCL-61 shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members. HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples.Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also results in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h.
背景
别名
HLCL61; HLCL 61; HLCL 61 hydrochloride
分子式
C23H25ClN2O
CAS号
1158279-20-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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