产品信息
抗原名称
MRN
商品描述
Mirin is a Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3‘ and 5‘ exonuclease activity associated with Mre11.
分子量
220.25
纯度
>98%
可溶性
DMSO : ≥ 31 mg/mL (140.75 mM)
外观
Yellow solid
In vitro(体外研究)
Mirin inhibits DSB-induced ATM activation, the ATM-dependent phosphorylation of the downstream targets Nbs1 and Chk2 and the MRN-dependent autophosphorylation of ATM at Ser1981 in response to DSBs. Mirin also inhibits the G2 checkpoint in TOSA4 cells, and homology-dependent DNA repair in HEK293 cells. In cells with integrated HPV16 (SiHa), Mirin sensitizes HPV episomes to PA25 resulting in a ∼5-fold reduction of the PA25 IC50. Pretreatment with mirin also decreases cell viability and inhibits proliferating cell nuclear antigen expression in cisplatin-treated human embryonic kidney 293 cells.
背景
分子式
C10H8N2O2S
CAS号
1198097-97-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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