产品信息
抗原名称
GLUT1
商品描述
STF-31 is an inhibitor of GLUT1 (IC50 = ~1 μM) that blocks glucose uptake.
分子量
423.5
纯度
>98%
可溶性
DMSO 85 mg/mL (200.69 mM)
Ethanol 25 mg/mL warmed (59.02 mM)
Ethanol 25 mg/mL warmed (59.02 mM)
外观
Powder
In vitro(体外研究)
STF-31 selectively kills RCCs by specifically targeting glucose uptake through GLUT1. STF-31 significantly inhibits lactate production and extracellular acidification in VHL-deficient cells by about 60%, and decreases glycolysis by decreasing glucose transport. In NAPRT1-expressing cells, STF-31 shows cytotoxicity by inhibiting the enzymatic activity of NAMPT. STF-31 is toxic to hPSCs and efficient for selective elimination of hPSCs from mixed cultures.
In vivo(体内研究)
In mice with VHL-deficient RCC xenografts, a more soluble analog of STF-31 (11.6 mg/kg, i.p.) markedly delays tumor growth.
背景
别名
STF31,STF 31
分子式
C23H25N3O3S
CAS号
724741-75-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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