产品信息
抗原名称
yeast Hmt1p ,human PRMT1
商品描述
AMI-1 is a PRMT and HIV-1 RT polymerase inhibitor.
分子量
592.42
纯度
>98%
可溶性
DMSO 100 mg/mL warmed (182.33 mM)
Water 10 mg/mL (18.23 mM)
PBS 22mg/mL
Water 10 mg/mL (18.23 mM)
PBS 22mg/mL
外观
Powder
In vitro(体外研究)
In HeLa cells, AMI-1 inhibits methylation levels of GFP-Npl3 fusion and endogenous PRMT1-like activity. AMI-1 also inhibits nuclear receptor-mediated transactivation of a luciferase reporter in MCF7 cells. In addition, AMI-1 inhibits HIV-1 RT polymerase activity with IC50 of 5 μM and inhibits DNA binding to HIV-1 RT with Kd of 2 μM. In INS-1 cells, AMI-1 improves INS-1 cell function and mediates translocations of FOXO1 and PDX-1 intracellularly by regulating FOXO1 phosphorylation and methylation.
In vivo(体内研究)
In chronic AIPI rats, AMI-1 (5 μg/rat) ameliorates COX2 expression and asthmatic indexes, and decreases the airway and alveoli lesions, mucus secretion, and collagen deposition in lungs.
背景
别名
AMI-1,AMI 1,AMI1
分子式
C21H12N2O9S2?4Na
CAS号
20324-87-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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