产品信息
抗原名称
IDO
商品描述
NLG-919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM.
分子量
282.38
纯度
>98%
可溶性
Ethanol ：30 mg/mL (106.23 mM)
DMSO ：15 mg/mL warmed (53.11 mM)
DMSO ：15 mg/mL warmed (53.11 mM)
外观
Powder
In vitro(体外研究)
NLG919 potently blocks IDO-induced T-cell suppression and restored robust T-cell responses with ED50 of 80 nM. Similarly, using IDO-expressing mouse DCs from tumor-draining lymph nodes, NLG919 abrogated IDO-induced suppression of antigen-specific T cells (OT-I) in vitro, with ED50 of 120 nM.
In vivo(体内研究)
In mice, a single oral administration of NLG919 reduces the concentration of plasma and tissue Kyn by ~ 50%. In mice bearing B16F10 tumors, NLG919 markedly enhances the antitumor responses of naive, resting pmel-1 cells to vaccination with cognate hgp100 peptide plus CpG-1826 in IFA.
背景
别名
NLG919, NLG 919, IDO INHIBITOR,GDC-0919,GDC 0919,GDC0919
分子式
C18H22N2O
CAS号
1402836-58-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
本文来自投稿，不代表本人立场，如若转载，请注明出处：http://www.iamyjet.com/article/13862.html