产品信息
抗原名称
Reverse transcriptase
商品描述
Rilpivirine(R 278474, TMC 278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI).
分子量
366.42
纯度
>98%
可溶性
DMSO : 50 mg/mL (136.46 mM; Need ultrasonic)
外观
Yellow powder
In vitro(体外研究)
Rilpivirine shows antiviral activity with EC50 ranging from 0.1 nM to 2 nM against wild-type and selected site-directed single and double mutants of HIV-1. Rilpivirine inhibits viral replication at concentrations at which first-generation NNRTIs could not suppress replication, and produces a high genetic barrier to resistance development.
In vivo(体内研究)
After iv administration of Rilpivirine, Elimination half-life ranges from 4.4 h in rat to 31 h in dog. After oral administration of Rilpivirine in PEG 400, half-life ranges between 2.8 h in rat and 39 h in dog.
背景
别名
利匹韦林
分子式
C22H18N6
CAS号
500287-72-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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