产品信息
抗原名称
Indoleamine 2,3-Dioxygenase (IDO)
商品描述
IDO5L is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 67 nM.
分子量
271.64
纯度
>98%
可溶性
DMSO 54 mg/mL warmed (198.79 mM)
Ethanol 54 mg/mL warmed (198.79 mM)
Ethanol 54 mg/mL warmed (198.79 mM)
外观
Powder
In vitro(体外研究)
IDO5L (Compound 5l) is a potent (HeLa IC50=19 nM) inhibitor of IDO. IDO5L is one of the highest potent inhibitors of the IDO1 (IC50=19 nM, in HeLa cell assay).
In vivo(体内研究)
Testing of IDO5L in mice demonstrates pharmacodynamic inhibition of IDO, as measured by decreased kynurenine levels (>50%) in plasma and dose dependent efficacy in mice bearing GM-CSF-secreting B16 melanoma tumors. Initial oral pharmacokinetic studies show that IDO5L is rapidly cleared (t1/250 (PBadjIC50=1.0 μM, murine cellular B16 IC50=46 nM). Notably, kynurenine levels increase back to baseline after 4 h as IDO5L exposure levels decreased below the mouse PBadjIC50 from 1.0 to 0.1 μM.
背景
别名
INCB-024360; INCB 024360; INCB-24360; indoleamine-2,3-dioxygenase inhibitor INCB024360
分子式
C9H7ClFN5O2
CAS号
914471-09-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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