S1QEL is a small molecule that suppresses superoxide production during reverse electron transport through the I_Q site of the mitochondrial respiratory complex I without affecting oxidative phosphorylation.¹ It has been shown to diminish endogenous oxidative damage in primary astrocytes, reduce stress-induced signaling in a cardiomyocyte cell model, and protect against ischemia-reperfusion injury in perfused mouse heart.¹

≥98%