产品信息
抗原名称
PRMT5
商品描述
EPZ015666 is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs.
分子量
383.44
纯度
>98%
可溶性
DMSO ：60 mg/mL warmed (156.47 mM)
Ethanol ：48 mg/mL warmed (125.18 mM)
Ethanol ：48 mg/mL warmed (125.18 mM)
外观
white to beige powder
In vitro(体外研究)
EPZ015666 shows potent cellular activity that blocks symmetric dimethylation of SmD3 and inhibit proliferation of MCL cell lines (Z-138, Granta-519, Maver-1, Mino, and Jeko-1) with IC50 of 96-904 nM.
In vivo(体内研究)
EPZ015666 (200 mg/kg, p.o.) displays robust anti-tumor activity in MCL xenograft animal models.
背景
别名
EPZ-015666；EPZ 015666；GSK3235025
分子式
C20H25N5O3
CAS号
1616391-65-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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