产品信息
抗原名称
Chymotrypsin-like proteasome
商品描述
PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor with IC50 of 27 nM with little effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L).
分子量
394.47
纯度
99.20 %
可溶性
DMSO : 72 mg/mL (182.5 mM)
Ethanol : 31 mg/mL (78.6 mM)
Ethanol : 31 mg/mL (78.6 mM)
In vitro(体外研究)
PI-1840 potently inhibits proteasomal CT-L activity with IC50 of 0.37 μM in intact human MDA-MB-468 cancer cells, and inhibits proliferation/survival of human MDA-MB-468 cells. In intact cancer cells, PI-1840 inhibits CT-L activity, induces the accumulation of proteasome substrates p27, Bax, and IκB-α, inhibits survival pathways and viability, and induces apoptosis.
In vivo(体内研究)
PI-1840 (150 mg/kg i.p.) inhibits the tumor growth in mice of MDA-MB-231 breast tumors.
背景
别名
PI 1840；PI1840
分子式
C22H26N4O3
CAS号
1401223-22-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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