产品信息
抗原名称
Aryl Hydrocarbon Receptor
商品描述
ITE is an Endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM).
分子量
286.3
纯度
>98%
可溶性
DMSO : ≥ 41 mg/mL (143.20 mM)
外观
Powder
In vitro(体外研究)
ITE is an endogenous agonist of AhR, binding directly to AHR, with a Ki of 3 nM. ITE (0.03-30 mg/mL) decreases the antigen-specific T-cell proliferative responses. ITE potently inhibits human pulmonary artery endothelial (HPAECs) growth at 10 and 20 µM, but shows no effect at 0.01-5 µM. ITE does not affect cell cycle progress of HPAECs at 10 and 20 µM, or induce expression of cleaved caspase-3 protein in HPAECs at 20 µM. In addition, ITE (20 µM) elevates CYP1A1 and CYP1B1 mRNA levels and decreases the levels of AhR protein in HPAECs.
In vivo(体内研究)
ITE (200 μg, i.p.) significantly suppresses the development of experimental autoimmune uveitis (EAU) in mice. ITE reduces the proportions of cells expressing IFN-γ, IL-17, or IL-10 in mice. ITE also suppresses the secretion of inflammatory cytokines by LN cells in mice.
背景
别名
Aryl hydrocarbon receptor ligand
分子式
C14H10N2O3S
CAS号
448906-42-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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