产品信息
抗原名称
LRRK2
商品描述
CZC-25146 is a potent and selective LRRK2 inhibitor. CZC-25146 prevents mutant LRRK2-induced injury of cultured rodent and human neurons with mid-nanomolar potency.
分子量
525.00
纯度
>98%
可溶性
DMSO : 15 mg/mL
In vitro(体外研究)
CZC-25146 inhibited only five kinases(PLK4, GAK, TNK1, CAMKK2, and PIP4K2C) with high potency. CZC-25146 neither caused cytotoxicity in human cortical neurons at concentrations below 5 μM over a seven-day treatment in culture nor did it block neuronal development in vitro.
In vivo(体内研究)
CZC-25146 possesses favorable pharmacokinetic properties, such as a volume of distribution of 5.4 L/kg and clearance of 2.3 L/hr/kg that render it suitable for in-vivo studies.
背景
别名
CZC-25146, CZC 25146, CZC25146,CZC25146 hydrochloride,CZC 25146 hydrochloride
分子式
C22H25FN6O4S.HCl
CAS号
1330003-04-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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