产品信息
抗原名称
COX-2
商品描述
Celecoxib是一种选择性COX-2抑制剂，在Sf9细胞中IC50为40 nM。
分子量
381.37
纯度
＞98%
可溶性
DMSO : 71 mg/mL (186.2 mM)
Ethanol : 31 mg/mL (81.3 mM)
Ethanol : 31 mg/mL (81.3 mM)
外观
白色至类白色粉末
In vitro(体外研究)
Celecoxib shows low sensitivity against COX-1 with IC50 of 15 μM. Celecoxib shows an anti-proliferative effect on nasopharyngeal carcinoma (NPC) cell lines including HNE1 and CNE1-LMP1 with IC50 of 32.86 μM and 61.31 μM, respectively.
In vivo(体内研究)
Celecoxib exhibits a potent, oral anti-inflammatory activity. Celecoxib reduces acute inflammation in the carrageenan edema assay and chronic inflammation in the adjuvant arthritis model with ED50 of 7.1 mg/kg and 0.37 mg/kg/day, respectively. In addition, Celecoxib also exhibits analgesic activity in the Hargreaves hyperalgesia model with ED50 of 34.5 mg/kg. Besides, Celecoxib produces no acute GI toxicity in rats at doses up to 200 mg/kg and no chronic GI toxicity in rats at doses up to 600 mg/kg/day over 10 days. In a C3Hf/KamLaw female mouse model, Celecoxib increases median survival time of 105 days (range, 79-145 days) after 13.5 Gy local thoracic irradiation (LTI) alone to 142 days (range, 94-155 days).
应用
实验应用
A selective Cox-2 inhibitor
背景
别名
塞来昔布；Celebra；Celebrex；SC 58635
分子式
C17H14F3N3O2S
CAS号
169590-42-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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