产品信息
抗原名称
C-Raf ,BRAF(V600E) ,BRAF WT
商品描述
LY3009120 is a potent and selective pan-RAF inhibitor with potential anticancer activity.
分子量
424.5
纯度
>98%
可溶性
DMSO ：3 mg/mL (7.06 mM)
外观
Powder
In vitro(体外研究)
LY3009120 inhibits the cell growth of A375 and HCT116 cells with the IC50 of 9.2 and 220 μM, respectively. LY3009120 inhibits the tyrosine kinase KDR with the IC50 of 3.9 μM.
In vivo(体内研究)
In rats bearing BRAF V600E ST019VR PDX tumors, LY3009120 (15 or 30 mg/kg, p.o.) shows a dose-dependent tumor growth inhibition. In nude rats bearing A375 xenograft, single dose oral treatment with LY3009120 (3 to 50 mg/kg, p.o.) shows a dose dependent inhibition of phospho-ERK, with a dose for 50% inhibition of phospho-ERK (EC50) of 4.36 mg/kg, with plasma concentration to achieve 50% inhibition of phospho-ERK (EC50) of 68.9 ng/mL or 165 nM.
背景
别名
LY3009120; LY-3009120; LY 3009120; DP-4978; DP 4978; DP4978
分子式
C23H29FN6O
CAS号
1454682-72-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
本文来自投稿，不代表本人立场，如若转载，请注明出处：http://www.iamyjet.com/article/17964.html