产品信息
抗原名称
PAI-1
商品描述
Inhibitor of plasminogen activator inhibitor-1 (PAI-1)
分子量
439.39
纯度
>98%
可溶性
DMSO 72 mg/mL (163.86 mM)
Ethanol 18 mg/mL warmed (40.96 mM)
2.0% Tween 80+0.5% methylcellulose 30mg/mL
Ethanol 18 mg/mL warmed (40.96 mM)
2.0% Tween 80+0.5% methylcellulose 30mg/mL
外观
Powder
In vitro(体外研究)
In a panel of human bladder cell lines, PAI-1 results in the reduction of cellular proliferation, cell adhesion, and colony formation, and the induction of apoptosis and anoikis.
In vivo(体内研究)
In a rat carotid thrombosis model, Tiplaxtinin (1 mg/kg, p.o.) increases time to occlusion and prevents the carotid blood flow reduction. In C57BL/6J mice, (1 mg/g chow) attenuates Ang II-induced aortic remodeling. In untreated type 1 diabetic mice, Tiplaxtinin (p.o.) restores skeletal muscle regeneration. In athymic mice bearing human cancer cell line T24 and HeLa xenografts, Tiplaxtinin (1 mg/kg, p.o.) reduces tumor xenograft growth, associated with a reduction in tumor angiogenesis, a reduction in cellular proliferation, and an increase in apoptosis.
背景
别名
Tiplaxtinin,PAI039,PAI 039
分子式
C24H16F3NO4
CAS号
393105-53-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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