产品信息
抗原名称
p53,Mdm2
商品描述
Tenovin-1 is a p53 activator and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.
分子量
369.48
纯度
＞98%
可溶性
DMSO ：74 mg/mL (200.28 mM)
外观
Powder
In vitro(体外研究)
Tenovin-1 is a p53 activator and elevates the amount of p53 protein within 2 hr of treatment. Tenovin-1 treatment does not alter p53 mRNA levels. Tenovin-1 (10μM) protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family.
In vivo(体内研究)
Initial in vivo experiments indicated that tenovin-1 impairs the growth of BL2-derived tumor xenografts.
背景
别名
Tenovin 1,Tenovin1
分子式
C20H23N3O2S
CAS号
380315-80-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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