产品信息
抗原名称
BRD4 (1),BRD4 (2)
商品描述
MS436 is a diazobenzene-based small-molecule inhibitor for the BRD4 bromodomains with a Ki value of 30-50 nM.
分子量
383.42
纯度
>98%
可溶性
DMSO: 25.5 mg/mL
外观
Powder
In vitro(体外研究)
MS436 exhibits low nanomolar affinity with preference for the first bromodomain over the second. MS436 effectively inhibits BRD4 activity in NF-κB-directed production of nitric oxide and proinflammatory cytokine interleukin-6 in murine macrophages without siginificanty inhibition on cell viability.
背景
别名
MS-436; MS 436
分子式
C18H17N5O3S
CAS号
1395084-25-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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