产品信息
抗原名称
ferroptosis
商品描述
Liproxstatin-1 is able to suppress ferroptosis in cells, in Gpx4(-/-) mice, and in a pre-clinical model of ischaemia/reperfusion-induced hepatic damage.
分子量
340.85
纯度
＞98%
可溶性
DMSO : 63 mg/mL (184.8 mM)
Ethanol : 16 mg/mL (46.9 mM)
Ethanol : 16 mg/mL (46.9 mM)
外观
white to light brown Powder
In vitro(体外研究)
Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4−/−cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4−/−cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H2O2 (200 µM).
In vivo(体内研究)
Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury.
背景
别名
利普司他丁-1
分子式
C19H21ClN4
CAS号
950455-15-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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