产品信息
抗原名称
EGFR；ErbB2
商品描述
Lapatinib ditosylate monohydrate (GW572016 ditosylate monohydrate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively.
分子量
943.47
纯度
>98%
可溶性
DMSO : 91 mg/mL (96.5 mM)
外观
淡黄色结晶性粉末
In vitro(体外研究)
Lapatinib (GW2016; 0.03-10 µM; 6 hours; BT474 and HN5 cells) treatment inhibits receptor autophosphorylation of EGFR and ErbB-2 in a dose-responsive manner. Phosphorylation of serine 473 of AKT was inhibited by GW2016 in a dose-dependent manner.
In vivo(体内研究)
Lapatinib (GW2016; 30-100 mg/kg; oral administration; twice daily; for 21 days; CD-1 nude female mice) treatment inhibits tumor xenograft growth of the HN5 cells in a dose-responsive manner at 30 and 100 mg/kg, with complete inhibition of tumor growth at the higher dose.
背景
别名
二甲苯磺酸拉帕替尼水合物；GW572016 ditosylate monohydrate； GW2016 ditosylate monohydrate
分子式
C29H26ClFN4O4S·2C7H8O3S·H2O
CAS号
388082-78-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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