产品信息
抗原名称
IKK
商品描述
MLN120B is a potent and effective IKKbeta inhibitor.
分子量
366.8
纯度
>98%
可溶性
DMSO: ≥ 31 mg/mL
In vitro(体外研究)
MLN120B inhibits both baseline and tumor necrosis factor-α-induced nuclear factor-κB activation, associated with down-regulation of IκBα and p65 nuclear factor-κB phosphorylation in multiple myeloma cells. MLN120B almost completely blocks stimulation of MM.1S, U266, and INA6 cell growth, as well as IL-6 secretion from BMSCs, induced by multiple myeloma cell adherence to BMSCs. MLN120B shows an inhibitory effect on LPS induced NF-κB activation in RAW267.4 cells. The IC50 values of MLN120B is 1.4, 14.8 or 27.3 µM for NF-κB2-luc2, IL8-luc2 or TNF-AIP3-luc2 reporter transfected cells, respectively.
In vivo(体内研究)
MLN120B (50 mg/kg, p.o.) inhibits human multiple myeloma cell growth in vivo. MLN120B (12 mg/kg twice daily, p.o.) inhibits paw swelling in a dose-dependent manner and offers significant protection against arthritis-induced weight loss as well as cartilage and bone erosion. NF-κB activity in arthritic joints is reduced after MLN120B administration.
背景
别名
ML120B, MLN 120B, MLN-120B
分子式
C19H15ClN4O2
CAS号
783348-36-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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