产品信息
抗原名称
Bcl-2 Family
商品描述
Bax inhibitor peptide V5, cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria; designed from Ku70, a protein that is suggested to suppress the mitochondrial translocation of Bax. Inhibits Bax-mediated apoptosis in vitro.
分子量
586.79
纯度
>98%
可溶性
DMSO: ≥ 30 mg/mL
In vitro(体外研究)
Bax inhibitor peptide V5 (0-50 μM) reduces cell death in STF-cMyc cells but not in SW620 or NCI-H23 cells. BIPV5 does not result in any significant effect on cell cycle arrest at the G2/M phase. V5 treatment upregulates expression of anti-apoptotic proteins Bcl-2 and XIAP by more than 3- and 11-fold and downregulates expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-κB-p65 by 10, 30, and nearly 50%, respectively.
In vivo(体内研究)
V5 (100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation in mice model.
背景
别名
Val-Pro-Met-Leu-Lys; BIP-V5; BAX Inhibiting Peptide V5
分子式
C27H50N6O6S
CAS号
579492-81-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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