产品信息
抗原名称
Trk Receptor
商品描述
LM22A-4 is a potent tropomyosin-related kinase B (TrkB) agonist (IC50 = 47 nM).
分子量
339.34
纯度
>98%
可溶性
DMSO: ≥ 29 mg/mL
外观
White solid
In vitro(体外研究)
LM22A-4 significantly up-regulates OPN and ALPase mRNA expression in a dose-dependent manner and OC mRNA level is significantly increased by 5 μM of LM22A-4. LM22A-4 significantly increases OPN, ALPase and OC mRNA expression in a time-dependent manner. LM22A-4 stimulated OPN and OC mRNA expression in HCEM cells cultured with mineralizing media.
In vivo(体内研究)
LM22A-4 (10 mg/kg, i.p.) significantly reduces the degree of tissue injury and apoptosis (TUNEL staining and caspase-3 and Bcl-2 expression) compared with vehicle treated group. LM22A-4 also significantly ameliorates the recovery of limb function. LM22A-4 (10 mg/kg) treatment results in a significant increase in neuron number. LM22A-4 administration (10 mg/kg) significantly improves the neurological scores compared with those of the solvent-treated animals.
背景
别名
LM 22A4, LM 22A-4
分子式
C15H21N3O6
CAS号
37988-18-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
本文来自投稿，不代表本人立场，如若转载，请注明出处：http://www.iamyjet.com/article/18511.html