产品信息
抗原名称
BACE2,BACE1
商品描述
Verubecestat (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.
分子量
409.41
纯度
>98%
可溶性
DMSO : ≥ 35 mg/mL (85.49 mM)
外观
Powder
In vitro(体外研究)
Verubecestat(MK-8931) effectively reduces Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM.
In vivo(体内研究)
Verubecestat(MK-8931) dramatically lowers CSF and cortex Aβ40 in both rats and cynomolgus monkeys following a single oral dose. Due to the 20 h half-life of MK-8931 it is ideal for once-a-day dosing.
背景
别名
MK8931,MK 8931,MK-8931
分子式
C17H17F2N5O3S
CAS号
1286770-55-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
本文来自投稿，不代表本人立场，如若转载，请注明出处：http://www.iamyjet.com/article/18569.html