产品信息
抗原名称
SIRT1
商品描述
SRT2104 (GSK2245840)是一种选择性 SIRT1 活化剂，参与能量平衡的调节。
分子量
516.64
纯度
＞98%
可溶性
DMSO Solubility: 16 mg/mL warmed (30.96 mM)
In vitro(体外研究)
SRT2104 reduces p65/RelA acetylation levels in C2C12 cells.
In vivo(体内研究)
In male C57BL/6J mice, SRT2104 (100 mg/kg, p.o.) extends both mean and maximal lifespan of mice fed a standard diet, and enhances motor coordination, bone mineral density, and insulin sensitivity and decreased inflammation. Short-term SRT2104 treatment preserves bone and muscle mass in an experimental model of atrophy. In Male N171-82Q HD mice, SRT2104 (diet containing 0.5% SRT2104) effectively penetrates the blood-brain barrier, attenuates brain atrophy, improves motor function, and extends survival.
背景
分子式
C26H24N6O2S2
CAS号
1093403-33-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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