产品信息
抗原名称
adiponectin receptor 1
商品描述
Arctiin, a plant lignan that can be extracted from the Arctium lappa (burdock) seeds, is a possible environmental endocrine disruptor compounds and have been shown to influence sex hormone metabolism as well as protein synthesis, steroid biosynthesis.
分子量
534.55
纯度
>98%
可溶性
DMSO : 93 mg/mL (174 mM)
Ethanol : 93 mg/mL (174 mM)
Water : 37 mg/mL (69.2 mM)
Ethanol : 93 mg/mL (174 mM)
Water : 37 mg/mL (69.2 mM)
外观
白色结晶性粉末
In vitro(体外研究)
Arctiin induces growth inhibition and dephosphorylates the tumor-suppressor retinoblastoma protein in human immortalized keratinocyte HaCaT cells. The growth inhibition caused by arctiin is associated with the downregulation of cyclin D1 protein expression. The arctiin-induced suppression of cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer.
In vivo(体内研究)
Arctiin has anti-cancer properties in animal models. arctiin has a remarkable anti-tumor-promoting effect as seen in a two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenzanthracene(DMBA) as an initiator and 12-Otetradecanoyl phorbol-13-acetate (TPA) as a promoter by topical and oral administration. It also has a protective effect on 2-amino-1-methyl-6-phenylimidazopyridine (PhIP)-induced carcinogenesis particularly in the mammary gland during the promotion period. Arctiin is orally effective against either IFV-inoculated normal or 5-fluorouracil (5-FU)-treated mice.
背景
别名
牛蒡苷；Arctii; NSC 315527; Arctigenin-4-glucoside
分子式
C27H34O11
CAS号
20362-31-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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