产品信息
商品描述
Solithromycin is a novel ketolide antibiotic.
分子量
845.02
纯度
>98%
可溶性
DMSO: ≥ 32 mg/mL
外观
White to off-white crystalline powder
In vitro(体外研究)
<p>The <b>IC<sub>50</sub></b>s values for Solithromycin on TNFα and CXCL8 release are 41.6 μM and 78.2 μM, respectively. Solithromycin markedly reduces MMP9 activity, with an <b>IC<sub>50</sub></b> of 14.9 μM<sup><a href="javascript:goCoordinate('cpd_References1');"></a></sup>.<br/> Solithromycin (0-333 μM; 72 hours; U937 and PBMC cells) suppresses lipopolysaccharide-induced TNFα release and phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase 9 (MMP9) activity, and does not affect cell viability in monocytic U937 and PBMC cells<sup><a href="javascript:goCoordinate('cpd_References1');"></a></sup>.</p>
In vivo(体内研究)
<p>Solithromycin (100 mg/kg; oral administration; every day; for 8 days; C57BL/6J mice) treatment inhibits inflammatory cells accumulation and pro-MMP9 production in cigarette smoke-exposed mice<sup><a href="javascript:goCoordinate('cpd_References1');"></a></sup>.</p>
背景
别名
索利霉素
分子式
C43H65FN6O10
CAS号
760981-83-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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