产品信息
抗原名称
iron
商品描述
Dp44mT is a potent iron chelator, which shows selective antitumor activity.
分子量
285.37
纯度
>98%
可溶性
DMSO ：57 mg/mL warmed (199.74 mM)
Ethanol ：47 mg/mL warmed (164.69 mM)
Water : Soluble
Ethanol ：47 mg/mL warmed (164.69 mM)
Water : Soluble
外观
yellow to orange Powder
In vitro(体外研究)
Dp44mT shows pronounced antiproliferative effects in SK-N-MC, SK-Mel-28, and MCF-7 cells with IC50 of 30 nM, 60 nM, and 60 nM, respectively, while no effects on normal MRC-5 fibroblasts. Dp44mT inhibits cellular Fe uptake from Fe-Tf in SK-N-MC neuroepithelioma and M109 cells, and induces cell apoptosis. In MDA-MB-231 cells, Dp44mT specifically targets topoisomerase topo2α, and thus causes DNA damage. Dp44mT, as a Pgp substrate, also overcomes multidrug resistance by the hijacking of lysosomal P-glycoprotein (Pgp).
In vivo(体内研究)
In CD2F1 mice bearing M109 tumors, Dp44mT (0.4 mg/kg, i.v.) inhibits tumor growth in a dose-dependent manner.
背景
别名
Iron Chelator, Dp44mT
分子式
C14H15N5S
CAS号
152095-12-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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